Regulatory Science and Drug Approval for Alcoholic and Nonalcoholic Steatohepatitis
نویسندگان
چکیده
منابع مشابه
Apoptosis in alcoholic and nonalcoholic steatohepatitis.
Alcohol liver disease (ALD) as well as nonalcoholic fatty liver disease (NAFLD) are two of the most common forms of chronic liver disease worldwide and may progress to cirrhosis and end stage liver disease. ALD and NAFLD seem to share many pathophysiologic mechanisms with the accumulation of lipids in the liver being the first step in the development of both conditions. While mitochondrial dysf...
متن کاملAlcoholic, Nonalcoholic, and Toxicant-Associated Steatohepatitis: Mechanistic Similarities and Differences
Hepatic steatosis and steatohepatitis are common histologic findings that can be caused by multiple etiologies. The three most frequent causes for steatosis/steatohepatitis are alcohol (alcoholic steatohepatitis, ASH), obesity/metabolic syndrome (nonalcoholic steatohepatitis, NASH), and environmental toxicants (toxicant-associated steatohepatitis, TASH). Hepatic steatosis is an early occurrence...
متن کاملTherapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis.
Alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH) are among the most frequent causes of chronic liver disease in the United States. Although the two entities are triggered by different etiologies - chronic alcohol consumption (ASH) and obesity-associated lipotoxicity (NASH) - they share overlapping histological and clinical features owing to common pathogenic mechanisms. T...
متن کاملNonalcoholic steatohepatitis and diabetes.
a Unidad de Hepatología, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España b Unitat de Suport a la Recerca (USR) Metropolitana Nord, Institut d’Investigació en Atenció Primaria (IDIAP) Jordi Gol, Centro de Investigación en Red de Enfermedades Hepáticas y Digesti...
متن کاملNonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is a well-recognized form of chronic liver disease affecting both children and adults that has gained increased recognition. Recently NAFLD has been associated with insulin resistance and its incidence and prevalence is likely increasing, paralleling the rise in obesity and diabetes mellitus in the United States. The article includes current thoughts on ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2016
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2016.02.044